Ochratoxin A-Induced Tumor Formation: Is There a Role of Reactive Ochratoxin A Metabolites?
نویسندگان
چکیده
منابع مشابه
Ochratoxin A-induced tumor formation: is there a role of reactive ochratoxin A metabolites?
Ochratoxin A is a nephrotoxic and tumorigenic mycotoxin which contaminates a variety of food items, resulting in chronic human exposure. Biotransformation reactions have been implicated in the tumorigenicity of ochratoxin A. The biotransformation of ochratoxin A by cytochromes P450 and other mammalian enzymes was investigated to optimize conditions for bacterial mutagenicity testing. Metabolite...
متن کاملOccurrence of Ochratoxin A in Grape Juice of Iran
Ochratoxin A (OTA) is one of the most important mycotoxins that contaminate a broad range of agricultural and food products. In this study, the occurrence of OTA in available brands of grape juice in Iran purchased from retail outlets or producer were determined for the first time using high-performance liquid chromatography (HPLC) with immunoaffinity columns(IAC) as the clean-up step. The aver...
متن کاملOccurrence of Ochratoxin A in Grape Juice of Iran
Ochratoxin A (OTA) is one of the most important mycotoxins that contaminate a broad range of agricultural and food products. In this study, the occurrence of OTA in available brands of grape juice in Iran purchased from retail outlets or producer were determined for the first time using high-performance liquid chromatography (HPLC) with immunoaffinity columns(IAC) as the clean-up step. The aver...
متن کاملCirculatory disorders induced by ochratoxin A
Ochratoxin A (OA) or (OTA) is a mycotoxin produced by certain Penecillium (mainly P. verrucosum) and Aspergillus (mainly A. occracies) species of storage fungi. This toxin is a secondary fungal metabolites which has been detected in a variety of animal chows, human food and in up to 80% of human blood samples of several Western countries. Its main target is the kidney which is the causing agent...
متن کاملBiosynthesis of ochratoxin A.
Biosynthesis of ochratoxin A by Aspergillus ochraceus Wilh. was investigated by radiolabeling experiments in which phenylalanine-1-(14)C and sodium acetate-2-(14)C were supplied to the fungus in sucrose-yeast extract medium. Results showed that phenylalanine was incorporated unaltered into the phenylalanine moiety of ochratoxin A, whereas the isocoumarin moiety of ochratoxin A was mostly derive...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2001
ISSN: 1096-0929
DOI: 10.1093/toxsci/59.1.59